HRID1981352

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID101

3-Hydroxybenzaldehyde

C7H6O2

HCID24758

Sodium hydride

HNa

HCID67164

Thiamorpholine

C4H9NS

HCID763337

Phenol, 3-(4-thiomorpholinylmethyl)-

C11H15NOS

HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

HCID11469095

3-Chloropropan-1-amine--hydrogen chloride (1/1)

C3H9Cl2N

PRODUCTS

生成物

HCID20151506

3-{3-[(Thiomorpholin-4-yl)methyl]phenoxy}propan-1-amine

C14H22N2OS

PROCEDURE

实验过程

By operating as described hereinabove, by reacting 0.2 mol of 3-hydroxybenzaldehyde with 0.4 mol of thiomorpholine in the presence of 0.2 mol of sodium borohydride (as in PREPARATION 1(a) 3-thiomorpholinomethylphenol is obtained, which, treated with an excess of 3-chloropropylamine hydrochloride in the presence of sodium hydride (as in PREPARATION 1(b), gives 3-(3-thiomorpholinomethylphenoxy)propylamine, in the form of an oil.

WORKUP

后处理

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