Acetic Anhydride → HCID 10767858, 화합물

HRID 1981937노트

반응식

HRID 1981937 반응식
Cl(O)(=O)(=O)=O.[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C@H:14]2[C@@H:20]([OH:21])[C:19](=[O:22])[N:18]([CH2:23][CH2:24][N:25]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH3:26])[C:17]3[CH:34]=[CH:35][C:36]([CH3:38])=[CH:37][C:16]=3[S:15]2)=[CH:10][CH:9]=1.[C:39](OC(=O)C)(=[O:41])[CH3:40]>N1C=CC=CC=1>[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C@H:14]2[C@@H:20]([O:21][C:39](=[O:41])[CH3:40])[C:19](=[O:22])[N:18]([CH2:23][CH2:24][N:25]([CH2:27][C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH3:26])[C:17]3[CH:34]=[CH:35][C:36]([CH3:38])=[CH:37][C:16]=3[S:15]2)=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 86740836(-)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-benzyl-N-methylamino)ethyl]-8-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one perchlorate

생성물 1

HCID 10767858HCID 10767858, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
100 °C

실험 절차

10.7 g of (-)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-benzyl-N-methylamino)ethyl]-8-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one perchlorate is converted to its free base, and 80 ml of acetic anhydride and one ml of pyridine are added thereto. The mixture is heated at 100° C. for 4 hours. The mixture is evaporated under reduced pressure to remove acetic anhydride and pyridine. Benzene is added to the residue, and the mixture is evaporated under reduced pressure to remove solvent. 10.37 g of (-)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(N-benzyl-N-methylamino)ethyl]-8-methyl- 2,3-dihydro-1,5-benzothiazepin-4(5H)-one are obtained as an oil.

후처리

  1. additionare added
  2. customThe mixture is evaporated under reduced pressure
  3. customto remove acetic anhydride and pyridine
  4. additionBenzene is added to the residue
  5. customthe mixture is evaporated under reduced pressure
  6. customto remove solvent

출처 및 근거

ORD 기록
ord-c06f7dd0f4fd4ea49116c3a4f2a63480
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04594342

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