Water → 3beta-Acetoxyandrost-5-en-17-one

HRID 1982

반응식

HRID 1982 반응식
[CH3:1][C@@:2]12[C:10](=[O:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH:13]=[C:14]3[CH2:19][C@@H:18]([OH:20])[CH2:17][CH2:16][C@:15]3([CH3:21])[C@H:5]1[CH2:4][CH2:3]2.[OH2:22].N1[CH:28]=[CH:27]C=CC=1>>[C:27]([O:20][C@H:18]1[CH2:17][CH2:16][C@@:15]2([CH3:21])[C:14](=[CH:13][CH2:12][C@@H:6]3[C@@H:5]2[CH2:4][CH2:3][C@@:2]2([CH3:1])[C@H:7]3[CH2:8][CH2:9][C:10]2=[O:11])[CH2:19]1)(=[O:22])[CH3:28]

참가 물질

4

반응물 3

HCID 962WaterHCID 1049PyridineHCID 5881Dehydroepiandrosterone

생성물 1

HCID 147093beta-Acetoxyandrost-5-en-17-one

실험 절차

Dehydroepiandrosterone (2.88 g, 10 mmol) is dissolved in a mixture (100 ml) of anhydride acetic and pyridine (1:1 v/v) and left at room temperature for 16 h. The mixture is then poured carefully into iced water and after 16 h, crystals are filtered and dried in vacuo.

후처리

  1. filtrationcrystals are filtered
  2. customdried in vacuo

출처 및 근거

ORD 기록
ord-929810e1bbe644d497f54844a1a40378
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728688

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