Hydrochloric Acid → 4-((5-Bromo-2-chlorophenyl)methyl)phenol

HRID 19823

반응식

HRID 19823 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16]C)=[CH:12][CH:11]=2)[CH:3]=1.B(Br)(Br)Br.C(=O)([O-])[O-].[K+].[K+].Cl>ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH:3]=1)[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 25134Boron tribromideHCID 223285944-Bromo-1-chloro-2-(4-methoxybenzyl)benzene

생성물 1

HCID 574237514-((5-Bromo-2-chlorophenyl)methyl)phenol

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 14.8 g 1-bromo-4-chloro-3-(4-methoxy-benzyl)-benzene in 150 mL dichloromethane is cooled in an ice bath. 50 mL of a 1 M solution of boron tribromide in dichloromethane are added and the resulting solution is stirred for 2 h at ambient temperature. The solution is then cooled in an ice bath again and saturated aqueous potassium carbonate solution is added dropwise. At ambient temperature the mixture is adjusted with aqueous 1 M hydrochloric acid to pH 1, the organic phase is separated off and the aqueous phase is extracted three times with ethyl acetate. The combined organic phases are dried over sodium sulfate and the solvent is removed completely.

후처리

  1. temperatureThe solution is then cooled in an ice bath again
  2. customAt ambient temperature
  3. customthe organic phase is separated off
  4. extractionthe aqueous phase is extracted three times with ethyl acetate
  5. dry with materialThe combined organic phases are dried over sodium sulfate
  6. customthe solvent is removed completely

출처 및 근거

ORD 기록
ord-1478545e3d4e4e06bc3aedf1e64970b7
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745414B2

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