Sodium Hydroxide → 2-(4-Phenyloxazol-5-yl)ethanol
반응식
[OH-].[Na+].C([O:5][CH2:6][CH2:7][C:8]1[O:12][CH:11]=[N:10][C:9]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=O>C(O)C.O>[OH:5][CH2:6][CH2:7][C:8]1[O:12][CH:11]=[N:10][C:9]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1참가 물질
5
실험 절차
2N Sodium hydroxide (40 ml) was added to a solution of 5-(2-formyloxyethyl)-4-phenyloxazole (12.9 g) in ethanol (40 ml). The mixture was stirred for 30 minutes, then diluted with water (80 ml) and extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was then distilled off to give 10.0 g (97.3%) of 5-(2-hydroxyethyl)-4-phenyloxazole as an oil.
후처리
- extractionextracted with ethyl acetate
- washThe ethyl acetate layer was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- distillationThe solvent was then distilled off
출처 및 근거
- ORD 기록
- ord-382b86bc03884424bd6aacab508aab4d
- 출처 데이터셋
- uspto-grants-1986_06
- 특허 번호
- US04596816
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