N-bromobutanimide → 3-Bromo-8-phenylimidazo[1,2-a]pyridine
반응식
[C:1]1([C:7]2[C:8]3[N:9]([CH:13]=[CH:14][N:15]=3)[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:16]N1C(=O)CCC1=O>C(Cl)Cl>[Br:16][C:13]1[N:9]2[CH:10]=[CH:11][CH:12]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:8]2=[N:15][CH:14]=1참가 물질
4
실험 절차
Combine 2 g (10.3 mmol) of the product from Example 4 with 1.8 g (10.3 mmol) of N-bromosuccinimide in 50 ml of methylene chloride, and stir for 10 minutes at room temperature. Wash the reaction mixture with 50 ml of 10% potassium carbonate. Dry the methylene chloride layer over sodium sulfate, treat with charcoal, filter, and remove the solvent in vacuo. Crystallize the residue from ether to provide the title compound.
후처리
- washWash the reaction mixture with 50 ml of 10% potassium carbonate
- dry with materialDry the methylene chloride layer over sodium sulfate
- additiontreat with charcoal
- filtrationfilter
- customremove the solvent in vacuo
- customCrystallize the residue from ether
출처 및 근거
- ORD 기록
- ord-72484a54a434498d87ac3b9620ad69f4
- 출처 데이터셋
- uspto-grants-1986_06
- 특허 번호
- US04596872
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