Formic Acid → HCID 13060164, 화합물

HRID 1982678노트

반응식

HRID 1982678 반응식
[C:1](OC(=O)C)(=[O:3])C.C(O)=O.[NH2:11][C:12]1[N:17]=[C:16]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:15]=[CH:14][CH:13]=1.O>C(OCC)(=O)C>[CH:1]([NH:11][C:12]1[N:17]=[C:16]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:15]=[CH:14][CH:13]=1)=[O:3]

참가 물질

6

반응물 4

HCID 284Formic AcidHCID 962WaterHCID 7918Acetic AnhydrideHCID 13060163Ethyl (6-aminopyridin-2-yl)acetate

생성물 1

HCID 13060164HCID 13060164, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Acetic anhydride (16.6 ml.) and 98% formic acid (7.32 ml.) were mixed at room temperature and stirred at 50° to 66° C. for 30 minutes. The solution was dropwise added to a solution of ethyl 2-(6-aminopyridin-2-yl)acetate (26.5 g.) in ethyl acetate (250 ml.) at 20° to 23° C. over 30 minutes, and stirred at the same temperature for one hour. Cool water was added to the resultant solution and shaked sufficiently. The ethyl acetate layer was separated, washed with water, an aqueous solution of sodium bicarbonate and water in turn, dried and concentrated under reduced pressure to give ethyl 2-(6-formamidopyridin-2-yl)acetate (28 g.), mp 35° to 38° C.

후처리

  1. stirringstirred at the same temperature for one hour
  2. customThe ethyl acetate layer was separated
  3. washwashed with water
  4. dry with materialan aqueous solution of sodium bicarbonate and water in turn, dried
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7c93147beff6473092bf8dbe7f572141
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04596869

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