Hydrochloric Acid → 2-(6-Aminopyridin-2-yl)-2-methoxyiminoacetic acid hydrochloride
반응식
C([NH:3][C:4]1[N:9]=[C:8]([C:10](=[N:14][O:15][CH3:16])[C:11]([OH:13])=[O:12])[CH:7]=[CH:6][CH:5]=1)=O.[ClH:17]>CO>[ClH:17].[NH2:3][C:4]1[N:9]=[C:8]([C:10](=[N:14][O:15][CH3:16])[C:11]([OH:13])=[O:12])[CH:7]=[CH:6][CH:5]=1참가 물질
4
실험 절차
A mixture of 2-(6-formamidopyridin-2-yl)-2-methoxyiminoacetic acid (syn isomer) (5.0 g.) and concentrated hydrochloric acid (2.34 g.) in methanol (50 ml.) was stirred for 40 minutes at ambient temperature. After the removal of methanol from the reaction mixture under reduced pressure, the residue was pulverized in diethyl ether, collected by filtration and then dried to give a pale brown powder of 2-(6-aminopyridin-2-yl)-2-methoxyiminoacetic acid hydrochloride (syn isomer) (5.2 g.).
후처리
- customAfter the removal of methanol from the reaction mixture under reduced pressure
- filtrationcollected by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-f47446147061463386c6c0a2da7b082b
- 출처 데이터셋
- uspto-grants-1986_06
- 특허 번호
- US04596869
반응 노트
불러오는 중…