Sodium Hydroxide → HCID 178441971, 화합물
반응식
[C:1]([C:5]1[CH:9]=[CH:8][NH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].[Br:12]Br>O>[Br:12][C:9]1[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[N:6][NH:7][CH:8]=1참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
2.48 g of 3-t-butyl-1H-pyrazole was suspended in 35 ml of water, and 2.5 g of 50% aqueous solution of sodium hydroxide was added to it. The mixture was cooled to 0° C., and then 3.50 g of bromine was added to the mixture, followed by stirring at room temperature for 7 hours. The reaction mixture was extracted by ethyl acetate. The organic layer was washed with water dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 3.14 of 4-bromo-3-t-butyl-1H-pyrazole.
후처리
- extractionThe reaction mixture was extracted by ethyl acetate
- washThe organic layer was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-6a99de2fe70a43438749455f0e89b660
- 출처 데이터셋
- uspto-grants-2009_06
- 특허 번호
- US07541374B2
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