Sodium Hydroxide → HCID 178506331, 화합물

HRID 1983044

반응식

HRID 1983044 반응식
[F:1][C:2]([F:12])([C:7]1[CH:11]=[CH:10][NH:9][N:8]=1)[C:3]([F:6])([F:5])[F:4].[OH-].[Na+].[Br:15]Br>O>[Br:15][C:11]1[C:7]([C:2]([F:1])([F:12])[C:3]([F:6])([F:5])[F:4])=[N:8][NH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 24408BromineHCID 1785063263-(pentafluoroethyl)-1H-pyrazole

생성물 1

HCID 178506331HCID 178506331, 화합물수율 103.6%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

9.30 g of 3-(pentafluoroethyl)-1H-pyrazole was suspended to 90 ml of water, and 6.0 g of 50% aqueous solution of sodium hydroxide was added to the suspension. The mixture was cooled to 0° C., then 8.79 g of bromine was added to the mixture, followed by stirring at room temperature for 7 hours. The reaction mixture was extracted by ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium salfate, filtered, and concentrated under reduced pressure to obtain 13.72 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole.

후처리

  1. additionwas added to the suspension
  2. extractionThe reaction mixture was extracted by ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialdried over anhydrous magnesium salfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c6db249ae75c4745986a803d2a414c46
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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