Hydrazine hydrate (1:1) → 3-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile

HRID 1983510노트

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HRID 1983510 반응식
F[C:2]1[C:9]([O:10][CH3:11])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1.O.[NH2:22][NH2:23]>C(O)C>[F:19][C:15]1[CH:14]=[C:13]([C:12]2[C:3]3[C:2](=[C:9]([O:10][CH3:11])[CH:8]=[C:5]([C:6]#[N:7])[CH:4]=3)[NH:23][N:22]=2)[CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 22260967HCID 22260967, 화합물

생성물 1

HCID 222608863-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

To a solution of 640 mg of 4-fluoro-3-(3-fluorobenzoyl)-5-methoxybenzonitrile in 6 ml ethanol was added 3 ml of hydrazine monohydrate at room temperature, followed by stirring at 70° C. for one day. The reaction mixture was evaporated, and the resulting crystals were collected by filtration. The crystals were sequentially washed with ethanol and diethyl ether, to give 590 mg of the title compound as colorless crystals.

후처리

  1. customThe reaction mixture was evaporated
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were sequentially washed with ethanol and diethyl ether

출처 및 근거

ORD 기록
ord-58255114aabb421e977e55ac387ed749
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541376B2

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