Ethyl formate → Rac-5-isopropyl-2-oxo-cyclohexanecarbaldehyde

HRID 1984204노트

반응식

HRID 1984204 반응식
[CH:1](OCC)=[O:2].C[O-].[Na+].[CH:9]([CH:12]1[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]1)([CH3:11])[CH3:10]>C(OCC)C>[CH:9]([CH:12]1[CH2:17][CH:16]([CH:1]=[O:2])[C:15](=[O:18])[CH2:14][CH2:13]1)([CH3:11])[CH3:10]

참가 물질

5

반응물 3

HCID 8025Ethyl formateHCID 794884-IsopropylcyclohexanoneHCID 10942334Sodium Methoxide

생성물 1

HCID 54180615Rac-5-isopropyl-2-oxo-cyclohexanecarbaldehyde

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of ethyl formate (6 mmol) in diethyl ether (2 ml) was added dropwise to a suspension of sodium methoxide (6 mmol) and 4-isopropyl-cyclohexanone (3 mmol) in absolute diethyl ether (3 ml) and after complete evolution of the gas the reaction mixture was stirred overnight at room temperature. The solid formed was filtered off, washed with diethyl ether and dried in a high vacuum. The product was obtained as a slightly yellow solid. tR 2.26; MS (pos. Ion.) m/z 169.32 [M+H]+. (J. Org. Chem. 2000, 65(21), 7145-7150).

후처리

  1. customThe solid formed
  2. filtrationwas filtered off
  3. washwashed with diethyl ether
  4. customdried in a high vacuum
  5. customThe product was obtained as a slightly yellow solid

출처 및 근거

ORD 기록
ord-099bedd1ca284d7eb6695a69f9a6e3f8
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544691B2

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