HCID 57717561, 화합물 → HCID 57717496, 화합물

HRID 1984499노트

반응식

HRID 1984499 반응식
[NH2:1][C:2]1[C:11]2=[N:12][N:13]([CH2:20][CH2:21][O:22][CH3:23])[C:14]([CH2:15][C:16]([CH3:19])([OH:18])[CH3:17])=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1>[Pt](=O)=O.FC(F)(F)C(O)=O>[NH2:1][C:2]1[C:11]2=[N:12][N:13]([CH2:20][CH2:21][O:22][CH3:23])[C:14]([CH2:15][C:16]([CH3:19])([OH:18])[CH3:17])=[C:10]2[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[N:3]=1

참가 물질

4

반응물 1

HCID 57717561HCID 57717561, 화합물

생성물 1

HCID 57717496HCID 57717496, 화합물수율 57.1%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 6422Trifluoroacetic acid용매

실험 절차

The methods described in Example 586 were used to hydrogenate 1-[4-amino-2-(2-methoxyethyl)-2H-pyrazolo[3,4-c]quinolin-1-yl]-2-methylpropan-2-ol (1.75 g, 5.5 mmol) in the presence of platinum (IV) oxide (1.5 g) and trifluoroacetic acid (20 mL) and purify the product with the modification that before recrystallization, the product was also triturated with acetonitrile. 1-[4-Amino-2-(2-methoxyethyl)-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-c]quinolin-1-yl]-2-methylpropan-2-ol (1.0 g) was obtained as white crystals, mp 163-165° C.

후처리

  1. custompurify the product with the modification
  2. customthat before recrystallization
  3. customthe product was also triturated with acetonitrile

출처 및 근거

ORD 기록
ord-8ba2e2c75b1845a3ab552122203681fc
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544697B2

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