Triphenylphosphine → HCID 57718000, 화합물

HRID 1984824노트

반응식

HRID 1984824 반응식
[CH3:1][O:2][C:3](=[O:37])[C@@H:4]([NH:13][C:14]([C:16]1[N:17]=[CH:18][C:19]2[C:24]([CH:25]=1)=[CH:23][C:22]([O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([CH3:36])([CH3:35])[CH3:34])=[CH:29][CH:28]=1)=[CH:21][CH:20]=2)=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[CH:38]1([CH2:43]O)[CH2:42][CH2:41][CH2:40][CH2:39]1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>C1COCC1>[CH3:1][O:2][C:3](=[O:37])[C@@H:4]([NH:13][C:14]([C:16]1[N:17]=[CH:18][C:19]2[C:24]([CH:25]=1)=[CH:23][C:22]([O:26][C:27]1[CH:28]=[CH:29][C:30]([C:33]([CH3:34])([CH3:36])[CH3:35])=[CH:31][CH:32]=1)=[CH:21][CH:20]=2)=[O:15])[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:12][CH2:43][CH:38]2[CH2:42][CH2:41][CH2:40][CH2:39]2)=[CH:10][CH:11]=1

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 77195CyclopentanemethanolHCID 5363146Diisopropyl azodicarboxylateHCID 57718031HCID 57718031, 화합물

생성물 1

HCID 57718000HCID 57718000, 화합물수율 46.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 50 mg (0.1 mmol) of (2S)-{[6-(4-tert-butyl-phenoxy)-isoquinoline-3-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionic acid methyl ester (Example 298) in dry THF (1 mL) was added cyclopentanemethanol (1.5 eq., 0.15 mmol, 0.016 mL), triphenylphosphine (1.5 eq., 0.15 mmol, 39 mg) and DIAD (1.5 eq., 0.15 mmol, 0.030 mL) according to the procedure M. Chromatography on silica using 20-30% ethyl acetate in hexanes afforded 27 mg of the title compound.

출처 및 근거

ORD 기록
ord-b5f21a0b696441618c3fff5d03831124
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544699B2

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