Methyl morpholine oxide → HCID 22926893, 화합물

HRID 1985292노트

반응식

HRID 1985292 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([O:18][CH:19]([CH3:21])[CH3:20])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C[N+]1([O-])CCOCC1>ClCCl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[CH:2]([C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([O:18][CH:19]([CH3:20])[CH3:21])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10])=[O:1]

참가 물질

5

반응물 2

HCID 82029Methyl morpholine oxideHCID 22494341HCID 22494341, 화합물

생성물 1

HCID 22926893HCID 22926893, 화합물수율 95.3%

시약·촉매·용매 2

HCID 178419074HCID 178419074, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

826 mg of Ethyl 3-[3-(hydroxymethyl)-4-methoxyphenyl]-2-isopropoxypropanoate was dissolved in 20 ml of dichloromethane, and 390 mg of N-methylmorpholine N-oxide, 1.4 g of molecular sieve 4A and 49 mg of tetrapropylammonium perruthenate were added, and the mixture was stirred at room temperature overnight. The reaction mixture was filtered through Celite, the filtrate was concentrated, and the residue was purified by silica gel column chromatography, to give 782 mg of the title compound in the 5:1→2:1 hexane-ethyl acetate fraction.

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated
  3. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-841fd412c5b9445dac495fe481d7264f
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544835B2

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