Hydrazine hydrate (1:1) → (1S,8R)-5-Isopropyl-1,11,11-trimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

HRID 1985609노트

반응식

[CH3:1][C@@:2]12[C:8]([CH3:10])([CH3:9])[C@@H:5]([CH2:6][CH2:7]1)[C:4](=O)[C:3]2=O.COP([CH2:19][C:20](=O)[CH:21]([CH3:23])[CH3:22])(=O)OC.O.[NH2:26][NH2:27]>>[CH:21]([C:20]1[CH:19]=[C:4]2[C:3]([C@:2]3([CH3:1])[C:8]([CH3:10])([CH3:9])[C@H:5]2[CH2:6][CH2:7]3)=[N:27][N:26]=1)([CH3:23])[CH3:22]

참가 물질

반응물 3

HCID 24654Hydrazine hydrate (1:1)

HCID 1549179(+)-Camphorquinone

HCID 12628547Dimethyl (3-methyl-2-oxobutyl)phosphonate

생성물 1

HCID 69065266(1S,8R)-5-Isopropyl-1,11,11-trimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

실험 절차

off-white crystalline solid. MS (ESI): 231.0 (MH+). Prepared from (1S,4R)-1,7,7-trimethyl-bicyclo[2.2.1]heptane-2,3-dione, (3-methyl-2-oxo-butyl)-phosphonic acid dimethyl ester, hydrazine monohydrate.

출처 및 근거

ORD 기록: ord-608ceb5c68814d91834f40f4f5344dbb
출처 데이터셋: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07547697B2

반응 노트

불러오는 중…