Sodium Hydroxide → 1-Ethyl-6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

HRID 1985630노트

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HRID 1985630 반응식
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([I:17])[CH:13]=2)[N:8]([CH2:18][CH3:19])[CH:7]=1)=[O:5])C.[OH-].[Na+]>C1COCC1.O>[CH2:18]([N:8]1[C:9]2[C:14](=[CH:13][C:12]([I:17])=[CH:11][CH:10]=2)[C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7]1)[CH3:19]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 57720090Ethyl 1-ethyl-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate

생성물 1

HCID 179804871-Ethyl-6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid수율 106.4%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
80 °C

실험 절차

1,4-Dihydro-1-ethyl-6-iodo-4-oxo-quinoline-3-carboxylic acid ethyl ester (7.5 g, 0.02 mol) was suspended in THF (75 mL), NaOH (2 equiv.) solution in water (75 mL) was added and the mixture was stirred at 80° C. for 24 hours. After THF was evaporated, the solution was acidified to pH 5 using HCl. The obtained precipitate was filtrated off and dried under reduced pressure yielding the title compound (7.3 g).

후처리

  1. customAfter THF was evaporated
  2. filtrationThe obtained precipitate was filtrated off
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-9cd744ffd07e4e70842c3402eec267e1
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07547679B2

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