(5-Fluoromethylpyridin-2-yl)methanol → 5-(Fluoromethyl)picolinaldehyde
반응식
[F:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][OH:10])=[N:7][CH:8]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[F:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[O:10])=[N:7][CH:8]=1참가 물질
4
실험 절차
Manganese dioxide (1.4 g) is added in a single portion to a solution of compound (5) (0.3 g) in chloroform (5 ml) at room temperature. The suspension is stirred vigorously for 7 hours and then diluted with chloroform and filtered through Celite. The filtrate is concentrated under vacuum and the yellow oil obtained (0.25 g) is used in its present form in the following reductive amination step.
후처리
- filtrationfiltered through Celite
- concentrationThe filtrate is concentrated under vacuum
- customthe yellow oil obtained (0.25 g)
출처 및 근거
- ORD 기록
- ord-b9294ab3250e4e2887e69d869f8f68e4
- 출처 데이터셋
- uspto-grants-2009_06
- 특허 번호
- US07547700B2
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