2-Amino-4-methylpyridine → N-[(4-methylpyridin-2-yl)carbamothioyl]benzamide

HRID 1985757

반응식

HRID 1985757 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[C:9]([N:17]=[C:18]=[S:19])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CC(C)=O>[C:9]([NH:17][C:18]([NH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1)=[S:19])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 15332-Amino-4-methylpyridineHCID 68284Benzoyl isothiocyanate

생성물 1

HCID 881443N-[(4-methylpyridin-2-yl)carbamothioyl]benzamide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of 2-amino-4-methylpyridine (1.08 g, 10 mmol) and benzoyl isothiocyanate (1.63 g, 10 mmol) in acetone (15 mL) was stirred at RT for 1.5 h. The precipitate formed was filtered and washed with acetone to afford 1-benzoyl-3-[4-methylpyridin-2-yl]-thiourea as a solid. This material was stirred with 2 N NaOH solution (15 mL) at 110° C. for 1 h, then cooled to RT, and the precipitate formed was washed with water and dried to provide (4-methylpyridin-2-yl)-thiourea (0.90 g, 53%). MS m/z 168 (M+H)+.

후처리

  1. customThe precipitate formed
  2. filtrationwas filtered
  3. washwashed with acetone

출처 및 근거

ORD 기록
ord-302fe9a461e84494bf6c4cc40a9d79b4
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07547711B2

연결된 노트

불러오는 중…