Tributylamine → HCID 178432402, 화합물

HRID 1986636노트

반응식

HRID 1986636 반응식
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.[CH:7]1([CH:12]([C:18](=O)[CH3:19])[C:13](OCC)=[O:14])[CH2:11][CH2:10][CH2:9][CH2:8]1.C(N(CCCC)CCCC)CCC>[OH-].[Na+]>[CH3:19][C:18]1[C:12]([CH:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)=[C:13]([OH:14])[N:3]2[N:4]=[CH:5][N:6]=[C:2]2[N:1]=1

참가 물질

5

반응물 3

HCID 7622TributylamineHCID 17750296Ethyl 2-cyclopentyl-3-oxobutanoateHCID 178418311HCID 178418311, 화합물

생성물 1

HCID 178432402HCID 178432402, 화합물수율 52.3%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

반응 조건

온도
180 °C

실험 절차

A mixture of 3-amino-1,2,4-triazole (14 g), ethyl 2-cyclopentyl-3-oxobutanoate (0.17 mol, Ex. 1) and tributylamine (50 ml) was heated at 180° C. for 6 hours. The reaction mixture was cooled to about 70° C., and aqueous NaOH solution (21 g in 200 ml of H2O) was then added and the solution was stirred for another 30 min. Following phase separation and extraction with diethyl ether, the aqueous phase was acidified with conc. HCl solution. The precipitate gave 19 g of the title compound.

후처리

  1. temperatureThe reaction mixture was cooled to about 70° C.
  2. customFollowing phase separation and extraction with diethyl ether

출처 및 근거

ORD 기록
ord-57d71b38b94e4789b7f567a5272e2cb5
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07550471B2

반응 노트

불러오는 중…