Hydrogen Bromide → HCID 23112415, 화합물

반응식

COC([N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[C:12]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:13]=3[S:14][CH:15]=2)[CH2:7][CH2:6]1)=O.[BrH:24]>>[BrH:24].[F:23][C:20]([F:21])([F:22])[C:17]1[CH:18]=[CH:19][C:12]2[C:11]([CH:8]3[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]3)=[CH:15][S:14][C:13]=2[CH:16]=1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 58817563HCID 58817563, 화합물

생성물 1

HCID 23112415HCID 23112415, 화합물수율 94%

실험 절차

A mixture of 4-(6-trifluoromethyl-benzo[b]thiophen-3-yl)-piperidine-1-carboxylic acid methyl ester (3.1 g, 9.0 mmol) in HBr (45 mL, 30% in acetic acid) was stirred at room temperature for 20 hours wher the volatiles were removed in vacuo. The residue was washed with EtOAc and the product was collected by filtration yielding 3.09 g (94%) of the desired product as a white solid.

후처리

customwere removed in vacuo
washThe residue was washed with EtOAc
filtrationthe product was collected by filtration

출처 및 근거

ORD 기록: ord-8dcc0f6530c14d43a1fa2d20fd227357
출처 데이터셋: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07550469B2

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