Water → HCID 68643629, 화합물

HRID 1987478노트

반응식

HRID 1987478 반응식
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17][CH3:18])=[O:10].[Al+3].[Cl-].[Cl-].[Cl-].C(S)CCCCCCCCCCC.O>CCCCCC.C(OCC)(=O)C>[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17][CH3:18])=[O:10]

참가 물질

6

반응물 4

HCID 962WaterHCID 81951-DodecanethiolHCID 6451240Aluminum(III) ChlorideHCID 247227562-Methoxy-2'-thiomethylbenzophenone

생성물 1

HCID 68643629HCID 68643629, 화합물수율 60%

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

To a mixture of 1.45 g (2-methoxyphenyl)(2-(methylthio)phenyl)methanone (G) and 1.437 g AlCl3 was added slowly 5 mL 1-dodecanethiol. The reaction was stirred overnight before 30 ml water was added. The mixture was extracted with ethyl acetate and the combined organic extracts were washed with brine, dried over magnesium sulfate, and the volatiles removed by distillation under nitrogen. Flash silica chromatography (hexane:ethyl acetate 80:20) afforded 0.807 g product (3.31 mmol, 60% yield).

후처리

  1. additionwas added
  2. extractionThe mixture was extracted with ethyl acetate
  3. washthe combined organic extracts were washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customthe volatiles removed by distillation under nitrogen

출처 및 근거

ORD 기록
ord-4e56929d85384e3593a65b0593a649ac
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07550505B2

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