Acetic Acid → HCID 68901947, 화합물

HRID 1987701노트

반응식

HRID 1987701 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)([O-:3])=[O:2].[I:15]N1C(=O)CCC1=O.C(O)(=O)C>CO>[I:15][C:12]1[S:11][C:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N+:1]([O-:3])=[O:2])=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 120273N-IodosuccinimideHCID 91672612-(2-nitrophenyl)thiophene

생성물 1

HCID 68901947HCID 68901947, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-(2-nitro-phenyl)-thiophene (23 g, 0.11 mol) and N-iodosuccinimide (37 g, 0.165 mol) were dissolved in 110 ml of methanol. To this solution, acetic acid (10 g, 0.165 mol) was added. After stirring the reaction mixture for 4 hours at room temperature, the solvent was evaporated. The remainder was taken up in a mixture of ice and water and extracted with ethyl acetate. The combined organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and brine, dried over magnesium sulfate and evaporated, delivering 2-iodo-5-(2-nitro-phenyl)-thiophene (28 g).

후처리

  1. customthe solvent was evaporated
  2. additionThe remainder was taken up in a mixture of ice and water
  3. extractionextracted with ethyl acetate
  4. washThe combined organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-abb13ff22a104882a68ed815deb540ba
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07553798B2

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