Sodium Hydroxide → HCID 67333043, 화합물

HRID 1988078노트

반응식

HRID 1988078 반응식
C[O:2][C:3](=[O:24])[CH2:4][CH2:5][CH:6]([NH:9][C:10]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)=[O:11])[CH2:7][OH:8].[OH-].[Na+]>C1COCC1.CO>[C:15]1([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:14]=[CH:13][C:12]([C:10]([NH:9][CH:6]([CH2:7][OH:8])[CH2:5][CH2:4][C:3]([OH:24])=[O:2])=[O:11])=[CH:17][CH:16]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 67332127HCID 67332127, 화합물

생성물 1

HCID 67333043HCID 67333043, 화합물수율 76.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4-[(Biphenyl-4-carbonyl)-amino]-5-hydroxy-pentanoic acid methyl ester (333 mg, 1.06 mmol) in THF (10 mL) and MeOH (1.27 mL) was added to 1N NaOH (1.27 mL, 1.27 mmol, 1.2 equiv) at room temperature. The mixture was stirred for 2 hours and TLC indicated the reaction was complete. Solvent was removed and the residue was dissolved in water. After adjusting the pH to 4 with 1N HCl, solid precipitated from the solution. The solid was then collected by filtration, washed with water, and dried under vacuum overnight to afford 240 mg of 4-[(Biphenyl-4-carbonyl)-amino]-5-hydroxy-pentanoic acid in 76.7% yield. MS (ESI) m/z 314.

후처리

  1. customSolvent was removed
  2. dissolutionthe residue was dissolved in water
  3. customprecipitated from the solution
  4. filtrationThe solid was then collected by filtration
  5. washwashed with water
  6. customdried under vacuum overnight

출처 및 근거

ORD 기록
ord-23a89e10c248450f881fbafcc64395cb
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07553873B2

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