Hydrochloric Acid → 3-(4-Amino-butyl)-7,8-dimethoxy-2a,3,4,5-tetrahydro-2H-3-aza-acenaphthylen-1-one dihydro-chloride

HRID 1988119

반응식

HRID 1988119 반응식
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[CH2:22][CH2:21][C:20]2[C:23]3[CH:13]1[CH2:14][C:15](=[O:28])[C:16]=3[C:17]([O:26][CH3:27])=[C:18]([O:24][CH3:25])[CH:19]=2)(C)(C)C.[ClH:30]>C(Cl)Cl.C(O)C.CCOCC>[ClH:30].[ClH:30].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[CH2:22][CH2:21][C:20]2[C:23]3[CH:13]1[CH2:14][C:15](=[O:28])[C:16]=3[C:17]([O:26][CH3:27])=[C:18]([O:24][CH3:25])[CH:19]=2

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 57729072[4-(7,8-Dimethoxy-1-oxo-2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen-3-yl)-butyl]-carbamic acid tert-butyl ester

생성물 1

HCID 673585823-(4-Amino-butyl)-7,8-dimethoxy-2a,3,4,5-tetrahydro-2H-3-aza-acenaphthylen-1-one dihydro-chloride수율 80%

시약·촉매·용매 3

HCID 702Ethanol용매HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

[4-(7,8-Dimethoxy-1-oxo-2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen-3-yl)-butyl]-carbamic acid tert-butyl ester (498 mg, 1.22 mmol) is dissolved in a mixture of CH2Cl2 (10 ml) and ethanol (2 ml) and a solution of 2 N HCl in Et2O is added (6 ml, 12 mmol). A brown precipitate appears, which is collected by filtration (367 mg, 80% yield).

후처리

  1. filtrationwhich is collected by filtration (367 mg, 80% yield)

출처 및 근거

ORD 기록
ord-b6577182b20c48d481f6d107a2db4c2e
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07553965B2

연결된 노트

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