Hydrochloric Acid → 2-Chloro-5-(2H-[1,2,3]triazol-4-yl)-benzoic acid
반응식
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([C:10]2[CH:14]=[N:13][NH:12][N:11]=2)[CH:7]=[CH:6][C:5]=1[Cl:15].[OH-].[K+].Cl>CO>[Cl:15][C:5]1[CH:6]=[CH:7][C:8]([C:10]2[CH:14]=[N:13][NH:12][N:11]=2)=[CH:9][C:4]=1[C:3]([OH:16])=[O:2]참가 물질
5
실험 절차
To a solution of 2-chloro-5-(2H-[1,2,3]triazol-4-yl)-benzoic acid methyl ester (0.095 g, 0.4 mmol) in methanol (2 mL) was added potassium hydroxide (0.25 g). The mixture was shaken at room temperature for 12 h. The mixture was diluted with methanol and acidified with HCl (2 mL, 6M). The mixture was concentrated in vacuo, diluted with water and sonicated. The solids were collected by filtration and washed with hexanes to afford the title compound (0.075 g).
후처리
- concentrationThe mixture was concentrated in vacuo
- additiondiluted with water
- customsonicated
- filtrationThe solids were collected by filtration
- washwashed with hexanes
출처 및 근거
- ORD 기록
- ord-9196471553794b4c9811eeec797c7905
- 출처 데이터셋
- uspto-grants-2009_06
- 특허 번호
- US07553972B2
반응 노트
불러오는 중…