Phosphorus oxychloride → 2-Chloro-4-(3-methyl-4-trifluoromethyl-phenyl)-6-methyl-pyrimidine

반응식

[CH3:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([CH3:18])[NH:15][C:14](=O)[N:13]=2)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].O=P(Cl)(Cl)[Cl:22]>>[Cl:22][C:14]1[N:13]=[C:12]([C:4]2[CH:5]=[CH:6][C:7]([C:8]([F:11])([F:10])[F:9])=[C:2]([CH3:1])[CH:3]=2)[CH:17]=[C:16]([CH3:18])[N:15]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 574686584-(3-Methyl-4-trifluoromethyl-phenyl)-6-methyl-1h-pyrimidin-2-one

생성물 1

HCID 574686572-Chloro-4-(3-methyl-4-trifluoromethyl-phenyl)-6-methyl-pyrimidine

실험 절차

The title compound was prepared from 4-(3-methyl-4-trifluoromethyl-phenyl)-6-methyl-1H-pyrimidin-2-one (1.73 g, 6.45 mmol) and phosphoroxychloride (20 mL) according to the general procedure I. Obtained as a brown solid (1.4 g, 76%). MS (EI) 286.1 [(M)+]; mp 101° C.

출처 및 근거

ORD 기록: ord-0271d0a024a34bd788fcac4cb9b1057a
출처 데이터셋: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07642264B2

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