Phosphorus oxychloride → 2-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine

반응식

[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[NH:12][C:11](=O)[N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].O=P(Cl)(Cl)[Cl:22]>>[Cl:22][C:11]1[N:10]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=2)[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 574686694-(3,4-Difluoro-phenyl)-6-trifluoromethyl-1h-pyrimidin-2-one

생성물 1

HCID 574686682-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine

실험 절차

The title compound was prepared from 4-(3,4-difluoro-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (14.7 g, 0.053 mol) and phosphoroxychloride (148 mL) according to the general procedure I. Obtained as a light brown solid (15.6 g, 99%). MS (EI) 294.0 [(M)+]; mp 53° C.

출처 및 근거

ORD 기록: ord-0836566bce25476fb0caf06d0a07357f
출처 데이터셋: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07642264B2

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