Benzyl Alcohol → 6-(Benzyloxy)pyridine-3-carbonitrile
반응식
Cl[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[CH2:10]([OH:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[H-].[Na+].C(OC(=O)C)C.O>C1COCC1>[CH2:10]([O:17][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1참가 물질
6
반응 조건
- 온도
- 0 °C
실험 절차
20 mmol of 6-Chloro-nicotinonitrile were dissolved in THF. 1.1 eq. of benzyl alcohol were added. The reaction mixture was cooled to 0° C. and flushed with argon. 4 eq of NaH were added slowly. After 15 min the product was isolated via extraction from ethylacetate/water.
후처리
- customflushed with argon
출처 및 근거
- ORD 기록
- ord-3b87310e94714395b9e6b08ddc99d610
- 출처 데이터셋
- uspto-grants-2010_01
- 특허 번호
- US07645776B2
반응 노트
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