Sodium Hydroxide → 4-(Methylsulfonamido)benzoic acid

HRID 1992236

반응식

HRID 1992236 반응식
[OH-].[Na+].[CH3:3][S:4]([NH:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]>CO.O>[CH3:3][S:4]([NH:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 669159Methyl 4-methanesulfonamidobenzoate

생성물 1

HCID 2506534-(Methylsulfonamido)benzoic acid수율 74.6%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

3.6 g (90 mmol) of NaOH was added to the solution of methyl 4-[(methylsulfonyl)amino]benzoate in 40 mL methanol and 20 mL water and stirred overnight at room temperature. Solvents were then removed and the product purified by ethyl acetate extraction from 1N aqueous hydrochloric acid, providing 1.2 g (yield 74.6%) of the 4-[(methylsulfonyl)amino]benzoic acid. 1H NMR in d-chloroform: 8.03 (2H, d, J=8.7 Hz), 7.34 (2H, d, J=8.7 Hz), 3.09 (3H, s). 13C NMR in d-chloroform: 131.2, 117.9, 38.6.

후처리

  1. customSolvents were then removed
  2. customthe product purified by ethyl acetate extraction from 1N aqueous hydrochloric acid

출처 및 근거

ORD 기록
ord-f82e1be2368949ec859bab25801deb71
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07645771B2

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