Triethylamine → N-(2-bromoethyl)-4-fluorobenzenesulfonamide
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Br.[Br:13][CH2:14][CH2:15][NH2:16].C(N(CC)CC)C>ClCCl.O>[Br:13][CH2:14][CH2:15][NH:16][S:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)(=[O:10])=[O:9]참가 물질
6
실험 절차
4-Fluoro benzene sulfonyl chloride (8 g, 0.0411 mol) was added dropwise at 0° C. to a solution of 2-bromoethylamine hydrogen bromide (10.27 g, 0.0501 mol) and triethyl amine (14.3 ml, 0.1029 mol) in dry dichloromethane (100 ml) and stirred at room temperature for 1 h under nitrogen atmosphere. The reaction mixture was diluted with water and extracted with ethyl acetate. Organic layer was washed with water and brine and dried over sodium sulfate. Solvent evaporation under reduced pressure afforded the sub-title product as a liquid. Yield: 11 g
후처리
- extractionextracted with ethyl acetate
- washOrganic layer was washed with water and brine
- dry with materialdried over sodium sulfate
- customSolvent evaporation under reduced pressure
출처 및 근거
- ORD 기록
- ord-6c84479aa6cf4876b0bc149ae09b6f2a
- 출처 데이터셋
- uspto-grants-2010_01
- 특허 번호
- US07648985B2
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