Sodium Hydroxide → 6,6,6-Trifluoro-3-{[3-(methyloxy)phenyl]methyl}hexanoic acid
반응식
[F:1][C:2]([F:22])([F:21])[CH2:3][CH2:4][CH:5]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=1)[CH2:6][C:7]([O:9]CC)=[O:8].[OH-].[Na+]>C1COCC1.CCO>[F:1][C:2]([F:21])([F:22])[CH2:3][CH2:4][CH:5]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=1)[CH2:6][C:7]([OH:9])=[O:8]참가 물질
5
실험 절차
Ethyl ester (119) (1.75 g, 5.50 mmol) was saponified with 1 N NaOH in THF and EtOH to give 1.56 g (98%) of the title compound (120) as a yellow oil. 1H NMR (400 MHz, CDCl3): δ 1.60-1.70 (m, 2H), 2.05-2.40 (m, 5H), 2.55-2.70 (m, 2H), 3.80 (s, 3H), 6.70-6.74 (m, 1H), 6.74-6.80 (m, 2H), 7.21 (t, J=7.9 Hz, 1H).
출처 및 근거
- ORD 기록
- ord-90be3f3a830a4f70bc4f6958a1007aad
- 출처 데이터셋
- uspto-grants-2010_01
- 특허 번호
- US07649093B2
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