Acetic Anhydride → HCID 68613661, 화합물

HRID 1993102노트

반응식

HRID 1993102 반응식
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[C:7]2[CH3:12].[C:13](OC(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([O:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[C:7]2[CH3:12])(=[O:15])[CH3:14]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 178306411-Methylisoquinolin-5-ol

생성물 1

HCID 68613661HCID 68613661, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

For example, 5-hydroxy-1-methylisoquinoline 64.9, prepared as described in J. Med. Chem., 1968, 11, 700, is reacted with acetic anhydride in pyridine to afford 5-acetoxy-1-methylisoquinoline 64.10. The latter compound is reacted with N-bromosuccinimide in refluxing ethyl acetate to yield 5-acetoxy-1-bromomethylisoquinoline 64.11. The product is then reacted with five molar equivalents of a trialkyl phosphite at 120° to give the phosphonate product 64.12. The acetoxy group is hydrolyzed by reaction with sodium bicarbonate in aqueous methanol as described in J. Am. Chem. Soc., 93, 746, 1971, to produce the phenol 64.13.

출처 및 근거

ORD 기록
ord-172d6d35377b4dc1987ff8d01f1fc96a
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07649015B2

반응 노트

불러오는 중…