참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 5-Hydroxyindole | HCID 16054 | — |
| 반응물 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 반응물 | Propan-2-one--water (1/1) | HCID 18366337 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-((6-Chloropyrimidin-4-yl)oxy)-1H-indole | HCID 57455156 | — |
반응 단계
To a mixture of NaOH (720 mg, 18 mmol) and acetone/water 1:1 (72 ml), 4,6-dichloropyrimidine (2.4 g, 18 mmol) and 5-hydroxy-indole (2.68 g, 18 mmol) are added. After stirring for 70 min at 65° C., the brownish solution is cooled to rt and diluted with AcOEt and water. The aqueous layer is separated off and extracted twice with AcOEt. The organic layers are washed with water, saturated Na2CO3 solution, water and brine, dried (Na2SO4) and concentrated. The crude product can be used without further purification: m.p.: 137-138° C.; MS: [M+1]+=246.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07652022B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_01 |
|---|
| ORD ID | ord-fda71291314b4954ab91941c4e258e26 |
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| 출처 메모 | uspto-grants-2010_01 |
|---|
