Hydrochloric Acid → HCID 86606498, 화합물

HRID 1994127노트

반응식

HRID 1994127 반응식
[CH3:1][O:2][CH2:3][C@@H:4]([NH:14]C(=O)OC(C)(C)C)[CH2:5][NH:6]C(=O)OC(C)(C)C.[ClH:22].CCOCC>CO>[ClH:22].[ClH:22].[CH3:1][O:2][CH2:3][C@@H:4]([NH2:14])[CH2:5][NH2:6]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 86606497HCID 86606497, 화합물

생성물 1

HCID 86606498HCID 86606498, 화합물수율 92%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of di-tert-butyl [(2S)-3-methoxypropane-1,2-diyl]biscarbamate (895 mg, 2.94 mmol) in MeOH (30 mL), was added 2N HCl in Et2O (15 mL, 29.4 mmol). The reaction was stirred at rt for 18 h and the solvents evaporated to yield the title compound as a white solid (478 mg, 92%). LCMS: (FA) ES+ 105.0 (M+1).

후처리

  1. customthe solvents evaporated

출처 및 근거

ORD 기록
ord-b3e21e47e2624ec1b97526b8155a2b5e
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652041B2

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