Acetic Anhydride → HCID 22145882, 화합물

HRID 1994354노트

반응식

HRID 1994354 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH3:12])[N+:6]([O-])=[N:7][C:8]=1[O:9][CH3:10].[C:13]([O:16]C(=O)C)(=[O:15])[CH3:14]>O>[C:13]([O:16][CH2:12][C:5]1[N:6]=[N:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:15])[CH3:14]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 21766149HCID 21766149, 화합물

생성물 1

HCID 22145882HCID 22145882, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 5,6-dimethoxy-3-methylpyridazine-2-oxide (0.5 g) in acetic anhydride (2 mL) is refluxed for 2 hours. After cooling the mixture is diluted with water and extracted with ethyl acetate (2×20 mL). The extracts are dried (MgSO4) and evaporated to give a brown oil which is purified by flash chromatography (ethyl acetate as eluent on silica) to give 6-acetoxymethyl-3,4-dimethoxypyridazine (0.27 g) as a colourless oil.

후처리

  1. temperatureis refluxed for 2 hours
  2. temperatureAfter cooling the mixture
  3. extractionextracted with ethyl acetate (2×20 mL)
  4. dry with materialThe extracts are dried (MgSO4)
  5. customevaporated
  6. customto give a brown oil which
  7. customis purified by flash chromatography (ethyl acetate as eluent on silica)

출처 및 근거

ORD 기록
ord-72e2a6315b434530867cc22e8042c153
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652144B2

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