Pyridine → 2-Hydrazinyl-5-phenylpyrazine

HRID 1995061

반응식

HRID 1995061 반응식
Cl[C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1.N1C=CC=CC=1.O.[NH2:21][NH2:22]>O>[NH:21]([C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1)[NH2:22]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 24654Hydrazine hydrate (1:1)HCID 12366642-Chloro-5-phenylpyrazine

생성물 1

HCID 131998672-Hydrazinyl-5-phenylpyrazine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 1.0 g. of 2-chloro-5-phenylpyrazine, m.p. 98°-99° C., 5.0 ml. of pyridine and 5.0 ml. of hydrazine hydrate is heated at reflux for 1.5 hours. The solution is cooled, and 20 ml. of water is added. The colorless crystalline product is collected and air dried. The crude product is recrystallized from aqueous ethanol to yield 0.35 g. of the product of the example as colorless needles, m.p. 128°-130° C.

후처리

  1. additionA mixture of 1.0 g
  2. temperatureat reflux for 1.5 hours
  3. temperatureThe solution is cooled
  4. customThe colorless crystalline product is collected
  5. customair dried
  6. customThe crude product is recrystallized from aqueous ethanol
  7. customto yield 0.35 g

출처 및 근거

ORD 기록
ord-21ffbdf0805c4b64b5feca5098d9f0ce
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04402958

연결된 노트

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