Sodium Hydroxide → HCID 12853039, 화합물

HRID 1995110노트

반응식

HRID 1995110 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][C:12](=[O:14])[CH:11]=[C:10]([CH3:15])[CH:9]1C(OCC)=O.[OH-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][C:12](=[O:14])[CH:11]=[C:10]([CH3:15])[CH2:9]1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 12853038HCID 12853038, 화합물

생성물 1

HCID 12853039HCID 12853039, 화합물수율 98.6%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To 5-(2-fluorophenyl)-3-methyl-4-carbethoxy-2-cyclohexen-1-one (57.3 g, 0.21 mole) was added a solution of sodium hydroxide (11.5 g, 0.29 mole) in 35 ml of ethanol and 80 ml of water. The stirred reaction mixture was heated under reflux for 8 hours. The ethanol was removed by evaporation under reduced pressure, and the residue was extracted with diethyl ether. The ether extract was dried over sodium sulfate and filtered. The filtrate was evaporated under reduced pressure to give 5-(2-fluorophenyl)-3-methyl-2-cyclohexen-1-one (42.3 g).

후처리

  1. customThe stirred reaction mixture
  2. temperaturewas heated
  3. temperatureunder reflux for 8 hours
  4. customThe ethanol was removed by evaporation under reduced pressure
  5. extractionthe residue was extracted with diethyl ether
  6. extractionThe ether extract
  7. dry with materialwas dried over sodium sulfate
  8. filtrationfiltered
  9. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-23a17709dabd457dae3426d9a106d504
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04402973

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