Dimethylformamide → 2-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

HRID 1995256노트

반응식

HRID 1995256 반응식
[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1.CN(C)C=O.S(Cl)([Cl:22])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10]([Cl:22])=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 129061732-[(2,6-Dichloropyridin-3-yl)oxy]propanoic acid

생성물 1

HCID 129061742-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

23.6 g (0.1 mole) of 2-[(2,6-dichloro-3-pyridyl)oxy]propionic acid, 150 ml of chloroform and 1.5 ml of dimethylformamide were heated with stirring at 55°, and an addition was then made dropwise in the course of 1 hour of a solution of 18 g (0.15 mole) of thionyl chloride in 40 ml of chloroform. The reaction mixture was subsequently refluxed for 16 hours and afterwards concentrated in vacuo. The resulting product was used directly for further reactions.

후처리

  1. additionan addition
  2. temperatureThe reaction mixture was subsequently refluxed for 16 hours
  3. concentrationafterwards concentrated in vacuo

출처 및 근거

ORD 기록
ord-0d83799187bd46c1866ebecc757701c5
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04404020

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