4D-083 → HCID 14450229, 화합물

HRID 1995345노트

반응식

HRID 1995345 반응식
[O:1]=[C:2]1[C:7]([C:8]([NH2:10])=O)=[CH:6][C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:4][NH:3]1>C(OC(=O)C)(=O)C>[O:1]=[C:2]1[C:7]([C:8]#[N:10])=[CH:6][C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:4][NH:3]1

참가 물질

3

반응물 1

HCID 14753284D-083

생성물 1

HCID 14450229HCID 14450229, 화합물

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

실험 절차

A mixture of 2,3-dihydro-3-oxo-6-phenyl-4-pyridazinecarboxamide (4.2 g) in 100 ml of acetic anhydride is heated under reflux for 6 hours. The acetic anhydride is removed by distillation and the residue is partitioned between ammonium hydroxide solution and dichloromethane. The dichloromethane layer is separated and concentrated on the rotary evaporator and the residue is recrystallized from ethanol to give 2,3-dihydro-3-oxo-6-phenyl-4-pyridazinecarbonitrile.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 6 hours
  3. customThe acetic anhydride is removed by distillation
  4. customthe residue is partitioned between ammonium hydroxide solution and dichloromethane
  5. customThe dichloromethane layer is separated
  6. concentrationconcentrated on the rotary evaporator
  7. customthe residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-7a7fc8ba17e14d108d5fe0783659d6cf
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04404203

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