2-Chloro-6-nitrotoluene → 2-Chloro-6-nitrobenzoic acid

HRID 1995392노트

반응식

HRID 1995392 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1[CH3:11].[Mn]([O-])(=O)(=O)=[O:13].[K+].[OH-:18].[K+]>O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1[C:11]([OH:13])=[O:18]

참가 물질

5

반응물 3

HCID 67402-Chloro-6-nitrotolueneHCID 14797Potassium HydroxideHCID 516875Potassium Permanganate2회

생성물 1

HCID 792872-Chloro-6-nitrobenzoic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 77.7 gm (0.453 mol) of 2-chloro-6-nitro-toluene, 190 gm (1.2 mol) of potassium permanganate, 500 ml of 1 N potassium hydroxide and 4 liters of water was heated for 8.5 hours at 100° C. After standing overnight, 25 gm (0.16 mol) of potassium permanganate were added, and the reaction mixture was heated for 2.5 hours more at 100° C. The unreacted starting material was distilled off by steam distillation. The remaining reaction solution was filtered, the filter cake was washed with hot water, and the combined filtrates were evaporated to about 750 ml. After acidifying with hydrochloric acid a precipitate was obtained, which was filtered off and dried.

후처리

  1. temperaturethe reaction mixture was heated for 2.5 hours more at 100° C
  2. distillationwas distilled off by steam distillation
  3. customThe remaining reaction solution
  4. filtrationwas filtered
  5. washthe filter cake was washed with hot water
  6. customthe combined filtrates were evaporated to about 750 ml
  7. customwas obtained
  8. filtrationwhich was filtered off
  9. customdried

출처 및 근거

ORD 기록
ord-5159393199984ed08503537ee2f7d5f0
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04404230

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