Acetic Acid → HCID 178514957, 화합물

HRID 1995840노트

반응식

HRID 1995840 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[N:3]=1.[C:9]1(=O)[O:14][C:12](=[O:13])[C:11]2[CH2:15][CH2:16][CH2:17][CH2:18][C:10]1=2.C(O)(=O)C>C(Cl)(Cl)Cl>[OH:8][C:4]1[N:3]=[C:2]([N:1]2[C:12](=[O:13])[C:11]3[CH2:15][CH2:16][CH2:17][CH2:18][C:10]=3[C:9]2=[O:14])[CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 124753,4,5,6-Tetrahydrophthalic anhydrideHCID 1785076342-Amino-6-hydroxypyridine

생성물 1

HCID 178514957HCID 178514957, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A mixture of 2-amino-6-hydroxypyridine (2.2 g), 3,4,5,6-tetrahydrophthalic anhydride (3.0 g) and acetic acid (40 ml) is heated to reflux for about 18 hours. The reaction is then cooled and stripped. The concentrate is taken up in CHCl3 (100 ml), washed with water, dried and stripped to yield N-(6-hydroxy-2-pyridyl)-3,4,5,6-tetrahydrophthalimide.

후처리

  1. temperatureis heated
  2. temperatureto reflux for about 18 hours
  3. temperatureThe reaction is then cooled
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-fecf112526254513bdfefa82450c79d8
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04406689

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