Protocatechuic Acid → Methyl 3,4-Dihydroxybenzoate

HRID 19984

반응식

HRID 19984 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].Cl.[CH3:13]O>>[CH3:13][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([OH:11])=[C:2]([OH:1])[CH:3]=1

참가 물질

4

반응물 3

HCID 72Protocatechuic AcidHCID 313Hydrochloric AcidHCID 887Methanol

생성물 1

HCID 287064Methyl 3,4-Dihydroxybenzoate수율 86.5%

실험 절차

A solution of 3,4-dihydroxy benzoic acid (2.8 g) in methanol (150 ml) was refluxed in presence of concentrated hydrochloric acid (0.5 ml) for 12 hrs. After concentrating under reduced pressure, the residue was dissolved in ethyl acetate (150 ml) and washed with water (50 ml) 10% sodium bicarbonate solution (50 ml), brine solution (50 ml) and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure provided 2.64 g of 3,4-dihydroxybenzoic acid methyl ester. (Yield 86.5%).

후처리

  1. concentrationAfter concentrating under reduced pressure
  2. dissolutionthe residue was dissolved in ethyl acetate (150 ml)
  3. washwashed with water (50 ml) 10% sodium bicarbonate solution (50 ml), brine solution (50 ml)
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customRemoval of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-10c90eac3e5d4cd08e4480474dc581bb
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745490B2

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