Carbon Monoxide → tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

HRID 2001317

반응식

HRID 2001317 반응식
CC[SiH](CC)CC.[C-:1]#[O+:2].[CH3:3][C:4]([O:7][C:8]([N:10]1[CH2:27][c:26]([c:13]2[CH2:12][CH2:11]1)[c:17]([O:18][CH2:19][c:20]3[cH:25][cH:24][cH:23][cH:22][cH:21]3)[cH:16][c:15](Br)[cH:14]2)=[O:9])([CH3:6])[CH3:5]>>[CH3:3][C:4]([O:7][C:8]([N:10]1[CH2:27][c:26]([c:13]2[CH2:12][CH2:11]1)[c:17]([O:18][CH2:19][c:20]3[cH:25][cH:24][cH:23][cH:22][cH:21]3)[cH:16][c:15]([CH:1]=[O:2])[cH:14]2)=[O:9])([CH3:6])[CH3:5]

참가 물질

8

반응물 3

HCID 281Carbon MonoxideHCID 6327258TriethylsiliconHCID 132189892tert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

생성물 1

HCID 132190424tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

시약·촉매·용매 4

HCID 81531Diisopropylethylamine시약HCID 178422001HCID 178422001, 화합물촉매HCID 6228Dimethylformamide용매HCID 117669-Phenylanthracene내부 표준

반응 조건

온도
80 °C

출처 및 근거

ORD 기록
ord-6e9f7fe0347b420d8c5bceda61d92cbb
출처 데이터셋
39k HTE dataset from Pfizer
원본 링크
출처 보기

연결된 노트

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