5-Bromopyrimidine → 1,2-Bis(1,1-dimethylethyl) 1-(5-pyrimidinyl)-1,2-hydrazinedicarboxylate

HRID 2022292노트

반응식

HRID 2022292 반응식
Br[c:1]1[cH:6][n:5][cH:4][n:3][cH:2]1.[CH3:7][C:8]([O:11][C:12]([NH:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])=[O:13])([CH3:10])[CH3:9]>>[CH3:7][C:8]([O:11][C:12]([NH:14][N:15]([c:1]1[cH:6][n:5][cH:4][n:3][cH:2]1)[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])=[O:13])([CH3:10])[CH3:9]

참가 물질

8

반응물 2

HCID 783445-BromopyrimidineHCID 85431Di-tert-butyl bicarbamate

생성물 1

HCID 722076241,2-Bis(1,1-dimethylethyl) 1-(5-pyrimidinyl)-1,2-hydrazinedicarboxylate

시약·촉매·용매 5

HCID 2733478Sodium 2-methylbutan-2-olate시약HCID 167845palladium(II) acetate촉매HCID 11618717Di-tert-butyl(2',4',6'-tris(propan-2-yl)-(1,1'-biphenyl)-2-yl)phosphane촉매HCID 312751,4-Dioxane용매HCID 117669-Phenylanthracene내부 표준

반응 조건

온도
110 °C

출처 및 근거

ORD 기록
ord-f10b1a6130964766a3ad413d2ea2398e
출처 데이터셋
39k HTE dataset from Pfizer
원본 링크
출처 보기

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