Nitromethane → 1-(3,5-Difluorophenyl)-2-nitroethanol
반응식
[N+:1]([CH3:4])([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([F:20])[CH:19]=1)[CH:15]=[O:16]>O1CCCC1>[F:11][C:12]1[CH:13]=[C:14]([CH:15]([OH:16])[CH2:4][N+:1]([O-:3])=[O:2])[CH:17]=[C:18]([F:20])[CH:19]=1참가 물질
5
실험 절차
Add nitromethane (200 mL) to a suspension of potassium carbonate (30 g) and 3,5-difluorobenzaldehyde (200 g) in tetrahydrofuran (600 mL) at room temperature. Stir at room temperature overnight, filter, wash with ethyl acetate and concentrate to give the desired compound as a crude oil (330 g) which is used in the next step without further purification.
후처리
- filtrationfilter
- washwash with ethyl acetate
- concentrationconcentrate
출처 및 근거
- ORD 기록
- ord-2cf9865e0403426b8bcade080e174cea
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745438B2
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