(Difluoromethyl)trimethylsilane → tert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
반응식
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:25][c:24]([c:11]2[CH2:10][CH2:9]1)[c:15]([O:16][CH2:17][c:18]3[cH:23][cH:22][cH:21][cH:20][cH:19]3)[cH:14][c:13](Br)[cH:12]2)=[O:7])([CH3:4])[CH3:3].C[Si]([CH:26]([F:28])[F:27])(C)C>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:25][c:24]([c:11]2[CH2:10][CH2:9]1)[c:15]([O:16][CH2:17][c:18]3[cH:23][cH:22][cH:21][cH:20][cH:19]3)[cH:14][c:13]([CH:26]([F:28])[F:27])[cH:12]2)=[O:7])([CH3:4])[CH3:3]참가 물질
8
반응물 2
생성물 1
시약·촉매·용매 5
반응 조건
- 온도
- 80 °C
출처 및 근거
- ORD 기록
- ord-027be02377e346bfbbac37e36b4ea3a3
- 출처 데이터셋
- 39k HTE dataset from Pfizer
- 원본 링크
- 출처 보기
반응 노트
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