홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → (2R,3R,4S)-2-Amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol

HRID 20342
노트
인쇄 미리보기

반응식

HRID 20342 반응식
C(OC([N:8]1[CH:12]([C@@H:13]([O:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C@@H:14]([N:24]([CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=2)[CH2:11][O:10]C1(C)C)=O)(C)(C)C.Cl>O1CCOCC1>[NH2:8][C@@H:12]([C@@H:13]([O:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[C@@H:14]([N:24]([CH2:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[CH2:15][C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=1)[CH2:11][OH:10]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 685580424-[(1S,2S)-1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

생성물 1

HCID 68559619(2R,3R,4S)-2-Amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol수율 114.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

Dissolve 4-[(1S,2S)-1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (2.42 g, 3.68 mmol) in dry dioxane (16 mL). To the solution add 4 M hydrogen chloride in 1,4-dioxane (32.2 mL, 129 mmol) and stir for three hours. Concentrate to give the hydrochloride salt of the desired product as a white solid (2.17 g, 100%). Slurry the solid in ethyl acetate (150 mL) and stir vigorously with saturated sodium bicarbonate (100 mL). Separate the layers and dry (magnesium sulfate) to give the desired compound.

후처리

  1. concentrationConcentrate

출처 및 근거

ORD 기록
ord-4d3283fa1b374872a9e9cf9ddcd6b3ef
출처 데이터셋
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07745438B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트