1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 131731010, 화합물

HRID 2035550노트

반응식

HRID 2035550 반응식
[CH2:1]([NH:8][C:9]1[CH:14]=[C:13]([N:15]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=2)[C:16]2[CH:17]=[N:18][C:19]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[CH:20][CH:21]=2)[N:12]=[CH:11][C:10]=1C(O)=O)C1C=CC=CC=1.Cl.[CH2:41]([N:43]=C=NCCCN(C)C)[CH3:42].[OH2:52].ON1[C:58]2[CH:59]=[CH:60][CH:61]=[CH:62][C:57]=2N=N1.O.N>ClCCl.O>[CH2:1]([NH:8][C:9]1[CH:14]=[C:13]([N:15]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=2)[C:16]2[CH:17]=[N:18][C:19]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[CH:20][CH:21]=2)[N:12]=[CH:11][C:10]=1[CH2:42][C:41]([NH2:43])=[O:52])[C:57]1[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=1

참가 물질

7

반응물 4

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrateHCID 12896473Azane;hydrateHCID 674139734-Benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid

생성물 1

HCID 131731010HCID 131731010, 화합물수율 86.1%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

3.4 mg of 4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid was dissolved in 1 mL of dichloromethane, to which 1.9 mg of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 1.5 mg of 1-hydroxybenzotriazole monohydrate were added, and stirred at room temperature for 30 minutes. Then, 1 mL of 28% ammonia water was added, and stirred at the same temperature for 3 hours. To the reaction mixture water was added, extracted with chloroform, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated to obtain 3.0 mg of the title compound containing impurities as a brown solid. Without further purification, this was used in the next reaction as it was.

후처리

  1. additionwere added
  2. stirringstirred at the same temperature for 3 hours
  3. extractionextracted with chloroform
  4. washthe extract was washed with saturated saline
  5. dry with materialdried on anhydrous sodium sulfate
  6. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-747b026ed676487c8e2dfc62e2928c1c
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575153B2

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