Ammonia → 1,2-Dihydroquinazolin-2-one

HRID 2037194

반응식

HRID 2037194 반응식
[C:1](O)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[C:11]([OH:14])(=O)C.C(N)=[NH:16].N>COCCO>[NH:4]1[C:3]2[C:2](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:1]=[N:16][C:11]1=[O:14]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 227Anthranilic AcidHCID 160693Formamidine acetate

생성물 1

HCID 3443811,2-Dihydroquinazolin-2-one

시약·촉매·용매 1

HCID 80192-Methoxyethanol용매

반응 조건

온도
125 °C

실험 절차

Anthranilic acid ED.5 (1.00 g, 4.27 mmol) is placed in 2-methoxyethanol (2.0 mL), combined with formamidine acetate (890 mg, 8.55 mmol) and heated to 125° C. for 20 h. The reaction mixture is added to aqueous NH3 (200 mL, 0.01 M), the precipitate is filtered off, dried and quinazolone Z.8 (817 mg, 79%) is obtained.

후처리

  1. filtrationthe precipitate is filtered off
  2. customdried

출처 및 근거

ORD 기록
ord-5ab1d869f9fe4fdda7a60a86251bb9ec
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575203B2

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